Isuzu i-280 MPG

The 2006 Isuzu i-280 gets 21 mpg combined (18 city, 25 highway): about $1,829 a year in fuel at $3.20 a gallon and 12,000 miles.

EPA fueleconomy.gov · 1 engines · 2006–2006 · Updated Nov 3, 2026
Quick answer

Against 265 other 4-cyl cars rated 2004–2006, the i-280 trails their 24.4 mpg average by 3.4 mpg, about $255 a year.

Every Isuzu i-280 engine, compared

The Isuzu i-280 was rated in a single specification, so its gas mileage does not vary by version — only by model year. Yearly cost assumes 12,000 miles at $3.20 a gallon.

FIG.01·Isuzu i-280 gas mileage by engine
EngineCombinedCity / HighwayYearsFuel per year
2.8L 4-cyl2118 / 252006–2006$1,829
ROWS 1·SOURCE EPA fueleconomy.gov + ForCar

What that actually costs

FIG.02·Isuzu i-280 fuel cost
MeasureValue
Cost per mile (2006)$0.152
Fuel per year$1,829
Fuel over five years$9,145
Against other 4-cyl cars, 2004–2006+$255 a year
EPA's own estimate$2,950 a year
ROWS 5·SOURCE ForCar, computed from EPA ratings

City or highway — who is this car for

The 2006 Isuzu i-280 gives up 7 mpg in town: 25 on the highway against 18 in the city, $597 a year if every mile were city driving.

FIG.03·Isuzu i-280 city versus highway
MeasureValueReading
City (2006)18 mpg$2,133 a year if you only drive in town
Highway25 mpg$1,536 a year if you mostly commute
Gap+7 mpg (39%)Wide — this car dislikes traffic
ROWS 3·SOURCE EPA fueleconomy.gov + ForCar

How the i-280 changed over the years

Combined figure across the 1 model year the i-280 was rated in, all of them at 21 mpg.

FIG.04·Isuzu i-280 gas mileage by model year
Model yearCombinedCity / HighwayEngines offeredFuel per year
20062118 / 251$1,829
ROWS 1·SOURCE EPA fueleconomy.gov + ForCar
Upgrade to Pro

MPG is a number. Dollars per year is the answer.

  • Fuel profile built from your actual mileage and local prices
  • Fuel tracker: what you really spend, month by month
  • Insurance and fuel folded into 5-year cost to own
  • Compare any two cars on total cost, not sticker price
  • No ads, no tracking — and much more
Free plan available — no credit card needed

How we count

This page rests on 1 EPA ratings of the Isuzu i-280 — 1 engine across 2006–2006. The mileage is EPA's laboratory figure, unchanged; the yearly bill is ours, at 12,000 miles and $3.20 a gallon, against EPA's own estimate of $2,950. Full method.

Frequently asked questions

What mpg does the 2006 Isuzu i-280 get?

21 mpg combined, 18 city and 25 highway, per EPA. Across every year since 2006 the i-280 has averaged 21 mpg.

Gas mileage ratings from EPA fueleconomy.gov, unadjusted. Running cost computed by ForCar at 12,000 miles a year and $3.20 a gallon. Last updated Nov 2026. — ForCar Reviewed by , founder of ForCar.
Found this useful?

Mark ForCar as a preferred source and our data shows up first in your Google results. One click, no account.

Prefer ForCar →