Isuzu i-350 MPG

The 2006 Isuzu i-350 gets 17 mpg combined (16 city, 21 highway): about $2,259 a year in fuel at $3.20 a gallon and 12,000 miles.

EPA fueleconomy.gov · 1 engines · 2006–2006 · Updated Nov 3, 2026
Quick answer

Against 33 other 5-cyl cars rated 2004–2006, the i-350 trails their 20.7 mpg average by 3.7 mpg, about $404 a year.

Every Isuzu i-350 engine, compared

The Isuzu i-350 was rated in a single specification, so its gas mileage does not vary by version — only by model year. Yearly cost assumes 12,000 miles at $3.20 a gallon.

FIG.01·Isuzu i-350 gas mileage by engine
EngineCombinedCity / HighwayYearsFuel per year
3.5L 5-cyl1716 / 212006–2006$2,259
ROWS 1·SOURCE EPA fueleconomy.gov + ForCar

What that actually costs

FIG.02·Isuzu i-350 fuel cost
MeasureValue
Cost per mile (2006)$0.188
Fuel per year$2,259
Fuel over five years$11,295
Against other 5-cyl cars, 2004–2006+$404 a year
EPA's own estimate$3,650 a year
ROWS 5·SOURCE ForCar, computed from EPA ratings

City or highway — who is this car for

The 2006 Isuzu i-350 gives up 5 mpg in town: 21 on the highway against 16 in the city, $571 a year if every mile were city driving.

FIG.03·Isuzu i-350 city versus highway
MeasureValueReading
City (2006)16 mpg$2,400 a year if you only drive in town
Highway21 mpg$1,829 a year if you mostly commute
Gap+5 mpg (31%)Wide — this car dislikes traffic
ROWS 3·SOURCE EPA fueleconomy.gov + ForCar

How the i-350 changed over the years

Combined figure across the 1 model year the i-350 was rated in, all of them at 17 mpg.

FIG.04·Isuzu i-350 gas mileage by model year
Model yearCombinedCity / HighwayEngines offeredFuel per year
20061716 / 211$2,259
ROWS 1·SOURCE EPA fueleconomy.gov + ForCar
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How we count

This page rests on 1 EPA ratings of the Isuzu i-350 — 1 engine across 2006–2006. The mileage is EPA's laboratory figure, unchanged; the yearly bill is ours, at 12,000 miles and $3.20 a gallon, against EPA's own estimate of $3,650. Full method.

Frequently asked questions

What mpg does the 2006 Isuzu i-350 get?

17 mpg combined, 16 city and 21 highway, per EPA. Across every year since 2006 the i-350 has averaged 17 mpg.

Gas mileage ratings from EPA fueleconomy.gov, unadjusted. Running cost computed by ForCar at 12,000 miles a year and $3.20 a gallon. Last updated Nov 2026. — ForCar Reviewed by , founder of ForCar.
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