Against 332 other Hybrid cars rated 2023–2025, the S6 trails their 27.7 mpg average by 5.7 mpg, about $359 a year. Averaged over the years each was sold, the most economical engine since 1995, the 2.9L 6-cyl Hybrid (2020–2025), does 22 mpg and the thirstiest, the 4.2L 8-cyl (2002–2003), 15: $815 a year apart.
Every Audi S6 engine, compared
Yearly cost assumes 12,000 miles at $3.20 a gallon.
| Engine | Combined | City / Highway | Years | Fuel per year |
|---|---|---|---|---|
| 2.9L 6-cyl Hybrid | 18.5 / 27.2 | 2020–2025 | $1,745 | |
| 4L 8-cyl | 17.2 / 26.5 | 2013–2018 | $1,920 | |
| 2.2L 5-cyl | 16 / 22 | 1995–1995 | $2,133 | |
| 5.2L 10-cyl | 14 / 19.4 | 2007–2011 | $2,400 | |
| 4.2L 8-cyl | 12.5 / 19 | 2002–2003 | $2,560 |
What that actually costs
Against its rivals in the same model years, the Honda Accord gets 40 mpg, the Infiniti Q50 23 mpg and the Kia K4 33.5 mpg, next to 22 mpg for the 2025 S6. The S6 costs the most of them to run: $785 a year more than the Honda Accord.
| Measure | Value |
|---|---|
| Cost per mile (2025) | $0.145 |
| Fuel per year | $1,745 |
| Fuel over five years | $8,725 |
| Against other Hybrid cars, 2023–2025 | +$359 a year |
| EPA's own estimate | $4,138 a year |
City or highway — who is this car for
The 2025 Audi S6 gives up 8 mpg in town: 27 on the highway against 19 in the city, $599 a year if every mile were city driving.
| Measure | Value | Reading |
|---|---|---|
| City (2025) | 19 mpg | $2,021 a year if you only drive in town |
| Highway | 27 mpg | $1,422 a year if you mostly commute |
| Gap | +8 mpg (42%) | Wide — this car dislikes traffic |
How the S6 changed over the years
The S6 peaked in 2025 at 22 mpg (19 city, 27 highway) and was at its thirstiest in 2003 at 15 — 7 mpg apart, or $815 a year in fuel between buying one year and the other. The biggest single-year change came in 2018: 21 to 18 mpg.
| Model year | Combined | City / Highway | Engines offered | Fuel per year |
|---|---|---|---|---|
| 2025 | 19 / 27 | 1 | $1,745 | |
| 2024 | 19 / 26 | 1 | $1,745 | |
| 2023 | 19 / 26 | 1 | $1,745 | |
| 2022 | 18 / 28 | 1 | $1,745 | |
| 2021 | 18 / 28 | 1 | $1,745 | |
| 2020 | 18 / 28 | 1 | $1,745 | |
| 2018 | 16 / 24 | 1 | $2,133 | |
| 2017 | 18 / 27 | 1 | $1,829 | |
| 2016 | 18 / 27 | 1 | $1,829 | |
| 2015 | 17 / 27 | 1 | $1,920 | |
| 2014 | 17 / 27 | 1 | $1,920 | |
| 2013 | 17 / 27 | 1 | $1,920 | |
| 2011 | 14 / 21 | 1 | $2,400 | |
| 2010 | 14 / 19 | 1 | $2,400 | |
| 2009 | 14 / 19 | 1 | $2,400 | |
| 2008 | 14 / 19 | 1 | $2,400 | |
| 2007 | 14 / 19 | 1 | $2,400 | |
| 2003 | 13 / 19 | 1 | $2,560 | |
| 2002 | 12 / 19 | 1 | $2,560 | |
| 1995 | 16 / 22 | 1 | $2,133 |
MPG is a number. Dollars per year is the answer.
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How we count
This page rests on 20 EPA ratings of the Audi S6 — 5 engines across 1995–2025. The mileage is EPA's laboratory figure, unchanged; the yearly bill is ours, at 12,000 miles and $3.20 a gallon, against EPA's own estimate of $4,138. Full method.
Frequently asked questions
What mpg does the 2025 Audi S6 get?
22 mpg combined, 19 city and 27 highway, per EPA. Across every year since 1995 the S6 has averaged 19 mpg.
Is the 2025 S6 more efficient than the 2024?
About the same: 22 against 22 mpg combined.
Which S6 year has the best gas mileage?
The 2025, at 22 mpg combined (19 city, 27 highway), which is also the latest model year we hold.
Does the S6 get better gas mileage than the Honda Accord?
No: 22 mpg for the 2025 S6 against 40 for the 2026 Honda Accord, about $785 a year more to run.
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